Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants

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Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants.

Multicellular organisms produce small cysteine-rich antimicrobial peptides as an innate defense against pathogens. While defensins, a well-known class of such peptides, are common among eukaryotes, there are other classes restricted to the plant kingdom. These include thionins, lipid transfer proteins and snakins. In earlier work, we identified several divergent classes of small putatively secr...

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Antimicrobial Peptides from Plants

Plant antimicrobial peptides (AMPs) have evolved differently from AMPs from other life forms. They are generally rich in cysteine residues which form multiple disulfides. In turn, the disulfides cross-braced plant AMPs as cystine-rich peptides to confer them with extraordinary high chemical, thermal and proteolytic stability. The cystine-rich or commonly known as cysteine-rich peptides (CRPs) o...

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Interactions of AsCy3 with Cysteine-Rich Peptides

There is great interest in fluorogenic compounds that tag biomolecules within cells. Biarsenicals are fluorogenic compounds that become fluorescent upon binding four proximal Cys thiols, a tetracysteine (Cys(4)) motif. This work details interactions between the biarsenical AsCy3 and Cys(4) peptides. Maximal affinity was observed when two Cys-Cys pairs were separated by at least 8 amino acids; t...

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Tryptophan-rich antimicrobial peptides: properties and applications

There is a world-wide quest for development of new-generation antibiotics, due to the emergence of microbial pathogens that have developed resistance to the currently available antibiotics. The antimicrobial peptides (AMPs) are a strong candidate in this regard, due to minimal possibilities of emergence of resistance against these. The tryptophan (Trp)-rich peptides comprise an important class ...

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Biologically Active and Antimicrobial Peptides from Plants

Bioactive peptides are part of an innate response elicited by most living forms. In plants, they are produced ubiquitously in roots, seeds, flowers, stems, and leaves, highlighting their physiological importance. While most of the bioactive peptides produced in plants possess microbicide properties, there is evidence that they are also involved in cellular signaling. Structurally, there is an o...

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ژورنال

عنوان ژورنال: The Plant Journal

سال: 2007

ISSN: 0960-7412

DOI: 10.1111/j.1365-313x.2007.03136.x